• br Roles of DDR in epithelial cell differentiation br

  2019-11-01

  

  Roles of DDR1 in epithelial cell differentiation Roles of DDR1 in cell migration, and invasion Dichotomous functions of DDR1 in disease progression Conclusions and perspectives The switch in amg express llc from DDR1 to DDR2 during EMT is another important issue. The DDRs may exert disti

• br Materials and methods br Results

  2019-10-31

  

  Materials and methods Results Discussion One novel finding in our study is that CK2 inhibition preserved axon function and structure in WM against ischemia. Consistent with these findings, oligodendrocytes, astrocytes, myelin, and CPI-455 were found to express CK2α. The robust expression p

• We continued to investigate the contribution of the EP

  2019-10-31

  

  We continued to investigate the contribution of the EP1 ikk to nociceptive sensitization by utilizing its natural ligand PGE and tested the effect of local subcutaneous injection of PGE (5nmol in 5μl) into one hindpaw on mechanical and heat pain thresholds. Wild-type mice displayed maximum sensitiz

• Ampicillin Trihydrate Glycolysis is important to maintain th

  2019-10-31

  

  Glycolysis is important to maintain the vital functions of T. gondi. Extracellular T. gondii shift its Ampicillin Trihydrate metabolism towards glycolysis, based on the observation that a relocation of glycolytic enzymes from the cytosol to the pellicle occurs at the time when tachyzoites egress fro

• br Conflict of Interest br Statement of Authorship br Introd

  2019-10-31

  

  Conflict of Interest Statement of Authorship Introduction Plant endopeptidases are involved in many important biological processes. Recent developments in molecular biological techniques have revealed trace amounts of endopeptidases play essential roles in plant development, turnover of pho

• br Discussion The regulation of intracellular cholesterol

  2019-10-31

  

  Discussion The regulation of intracellular cholesterol levels is a biological process of vital importance for cellular function and integrity, and involves robust transcriptional and post-transcriptional mechanisms that are sensitive to metabolic feedback control. Amongst post-transcriptional mec

• Structural changes within the heteromer

  2019-10-31

  

  Structural changes within the heteromer induced by agonist administration show a high level of complication. The presented results obtained in quantitative FLIM-FRET measurements with two selective ligands match the qualitative conclusions indicated by changes in the intracellular calcium level. The

• In general the DNMT encompass three

  2019-10-31

  

  In general, the DNMT encompass three different structural regions: N-terminal regulatory domain, C-terminal catalytic domain and a central linker region (). The N-terminal regulatory domain is particularly implicated in determining subcellular localization of the DNMT and in allocating unmethylated

• br Material and methods br Results br Discussion Ligase

  2019-10-31

  

  Material and methods Results Discussion Ligase IV is essential for the final ligation of DSBs through the NHEJ pathway. Its co-factor, XRCC4, has been shown to be important for increasing its activity and stability. Interaction between these two factors have been mapped to the linker region

• Unlike CRM exportins Cse and Xpot

  2019-10-31

  

  Unlike CRM1, exportins Cse1 and Xpot lack a C-extension and instead rely primarily on changes in HEAT-repeat conformation and direct Ran-cargo contacts to ensure low cargo-binding affinity in the cytosol and cooperative assembly of the exportin/Ran/cargo complex in the nucleus (Cook et al., 2005, Co

• Since its inception ADEPT approach has been widely reported

  2019-10-31

  

  Since its inception, ADEPT approach has been widely reported by many groups using a variety of enzymes and prodrugs (see reviews) [12], [14]. Both mammalian and non-mammalian enzymes have been utilised. Of the mammalian variety, human β-glucuronidase in combination with many prodrugs [17], [18] and

• It is well known that

  2019-10-31

  

  It is well known that the tumor suppressor p53 plays an important role in regulating the BIIB021 and cellular senescence [43,46,48]. For example, FOXO4 could interact with P53, which selectively induced apoptosis in senescent cells [48]. In addition, loss of MECP2 was found to lead to the induction

• br Funding This work was partly supported by the

  2019-10-30

  

  Funding This work was partly supported by the grant ‘Maria Grazia Cuccoli’ from Fondazione Cassa di Risparmio di Bologna. Declarations of interest Acknowledgements Introduction The main strategy of oncolytic viral therapy is based on the fact that naturally occurring or engineered virus

• br Introduction The innate immune

  2019-10-30

  

  Introduction The innate immune system stands the first line of the defense that protects the host from viral intrusion, depending on pattern recognition receptors (PRRs) and the corresponding pathways [[1], [2], [3], [4]]. The pathogen-associated molecular patterns (PAMPs) of the invading viruses

• br Conflict of interest br Acknowledgements The authors are

  2019-10-30

  

  Conflict of interest Acknowledgements The authors are grateful to laboratory technician Kristina Andersson for expert technical assistance. The authors acknowledge the Swedish Research Council (Grant no. 6834), Region Skåne and Faculty of Medicine, Lund University, for financial support. In

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