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Notochord is a transient structure differentiating at early
2019-12-09
Notochord is a transient structure differentiating at early stage during embryogenesis that is at the origin of vertebral bodies in all vertebrates. In zebrafish, it is composed of vacuolated S1RA surrounded by a unique ECM structure improperly called notochordal BM. As in chicken and amphibians, t
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During the course of enzymatic digestion protein is
2019-12-06
During the course of enzymatic digestion, protein is digested into large peptides and these large peptides are then further digested into small fragments. αs1-Casein f15–39, which contains 25 amino Neochlorogenic acid residues was the longest iTRAQ-labelled peptide identified in the samples digeste
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In the phase I AURA trial patients with EGFR activating
2019-12-06
In the phase I AURA trial, patients with EGFR activating mutations and centrally confirmed tumor and/or plasma genotyping (BEAMing) T790M result were enrolled. Among 216 patients with both plasma and tissue genotyping results, the concordance rate was 82% for cfse sale 19 deletions, 86% for L858R a
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Recent results from our group found that SPMs not only
2019-12-06
Recent results from our group found that SPMs, not only play a part in terminating inflammation, but also have a physiological role in conjunctival goblet FTY720 Phosphate to maintain ocular surface health in the absence of disease. Amongst the SPMs that are effective in the conjunctiva are resolvin
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br Materials and methods br Results
2019-12-06
Materials and methods Results Conclusion Conflict of interest Acknowledgements This work was supported by the National Key Research and Development Program of China (2018YFD0400302) and General Program of National Natural Science Foundation of China (31471602). Introduction A sign
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Support for Cloninger s personality theory
2019-12-06
Support for Cloninger\'s personality theory comes also from molecular genetic studies. Given the high heritability of personality it is plausible that gene variants explain variance in RD. In 69 2 to endocrine studies, which relate hormone levels mostly in the periphery (blood, saliva, urine) to pe
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In this study we have developed and investigated three
2019-12-06
In this study we have developed and investigated three NADPH-regenerating fusion partners with two different enzyme systems: a BVMO and an ADH. With the exception of one fusion construct (StGDH with LbADH), all fusion Mouse iPSC Chemical Reprogramming Cocktails Kit plus resulted in good soluble exp
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br Use of recombinant collagen to study DDR
2019-12-06
Use of recombinant collagen to study DDR–collagen interactions Synthetic peptides have proven highly valuable in replicating the characteristics of collagen and in defining the sites on collagen essential for binding and studying protein–collagen interactions. There are, however, disadvantages to
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br Introduction The discoidin domain receptors DDRs DDR
2019-12-06
Introduction The discoidin domain receptors (DDRs), DDR1 and DDR2, are unique among the receptor tyrosine kinases (RTKs) in being activated by interaction with the extracellular matrix [1], [2]. Binding to triple-helical collagen is mediated by the receptor extracellular domains that include an N
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The protein levels of the three enzymes
2019-12-06
The protein levels of the three enzymes in the organs in the three earthworm species ranked body wall > intestine > seminal receptacle ≈ seminal vesicle (Fig. 3B).The presence of significant detoxification capability in the body wall would be logically expected in a soil dwelling organism, to facili
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br Material and methods br Results and
2019-12-05
Material and methods Results and discussion Conclusions Acknowledgements S. De thanks DST, New Delhi for generous grant of the SERC Fast Track Scheme No. SR/FT/CS-057/2008. R. Kundu thanks the University of Kalyani for financial assistance. We are grateful to Prof. K. Bhattacharyya of IA
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When a hour delay period was implemented
2019-12-05
When a 6-hour delay 2-D08 was implemented for the WRAM, neither of the E2-treated groups (E2-only and E2 + Levo) differed in WMC errors between the postdelay trials and the baseline trials. This suggests that exogenous E2 treatment protected from a delay-induced impairment in performance on working
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Studies have recently raised concerns about
2019-12-05
Studies have recently raised concerns about the potential role of parabens in breast cancer, as these chemicals are commonly detectable in human breast cancer tissues. An analysis of 160 breast tissue samples collected from 40 mastectomies for primary breast cancer in England showed that at least on
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br Materials and Methods br Author Contributions br
2019-12-05
Materials and Methods Author Contributions Conflicts of Interest Acknowledgments This work was sponsored by the National Natural Science Foundation of China (81802517), the Integrated Traditional Chinese and Western Medicine of Shanghai (ZHYY-ZXYJHZX-1-03), the Clinical Research Program
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In the present study promoting bile acid synthesis by
2019-12-05
In the present study, promoting bile PFK-015 synthesis by activating EP4 receptors was shown to exert protection against hepatic steatosis. This finding may be relevant for treatment of non-alcoholic fatty liver disease, a major cause of liver disease and prominent indication for liver transplantati
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