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br Results br Discussion Cardiac dysfunction
2024-07-29
Results Discussion Cardiac dysfunction, common complication of severe sepsis, is one cause of death in intensive care units. Accumulated evidence revealed the regulatory effect of autophagy on sepsis-induced cardiac dysfunction [15], [22], although the mechanisms in young and aging are not elu
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Voreloxin Imaging QTL studies may have several potential
2024-07-29
Imaging QTL studies may have several potential advantages over case-control studies, including increased power . Imaging endophenotypes of disease in QTL studies can separate patients and normal subjects more accurately and therefore limit the confound of including asymptomatic subjects in the contr
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For comprehensive understanding of actin myosin XI as a cont
2024-07-29
For comprehensive understanding of actin-myosin XI as a control network, it will be necessary to determine the functions of all the myosin XI and abk isoforms. However, it is difficult to reveal the function of individual myosin XI isoforms because most myosin XI single knockouts exhibited no signi
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br Conflict of interest br Financial support br Acknowledgme
2024-07-29
Conflict of interest Financial support Acknowledgments This work was supported by the Japanese Millennium project. We thank all members of the Center for Genomic Medicine of RIKEN and Dainippon-Sumitomo Pharma Co., Ltd. for supporting this study. We are also grateful to members of the Hiros
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Introduction Myasthenia gravis MG is an autoimmune disorder
2024-07-29
Introduction Myasthenia gravis (MG) is an autoimmune disorder characterized by muscle weakness, which is mainly due to autoantibodies reducing the number or function of postsynaptic Hydroxysafflor yellow A receptors (AChRs) [1], [2]. Animal models have been developed to uncover the immunopathogene
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However cancer and fibrotic diseases are the most extensivel
2024-07-29
However, cancer and fibrotic diseases are the most extensively studied disease states. ATX is connected to various cancers because it can stimulate chemokinesis and chemotaxis in melanoma cells. Upregulated ATX N1-Methyl-ATP receptor has been reported in breast cancer,, prostate cancer, thyroid canc
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br Research perspective In vitro and in vivo studies have
2024-07-29
Research perspective In vitro and in vivo studies have demonstrated that increased LPA/ATX signaling contributes to cancer initiation and progression. Recent findings on the role of non-tumoral ATX in cancer progression and metastasis highlighted a new functional contribution for the microenviron
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Although plant Aurora kinases can be clearly
2024-07-29
Although plant Aurora kinases can be clearly grouped into functional clades, the roles of the respective clades does not seem to be evolutionarily conserved. AtAurora 1 labels kinetochore microtubules [19], similarly to mammalian Aurora A, while its targeting to the cell plate resembles features of
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The following are the supplementary data
2024-07-26
The following are the supplementary data related to this article. Competing interest Ethics approval and consent to participate Authors' contributions Acknowledgements The authors thank Dr. D. R. Kaplan for kind advice and materials derived from NB primary cell lines, Dr. F. D. Miller f
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Eribulin The functional similarity between GPR
2024-07-26
The functional similarity between GPR25 and APLNR, ie both can be activated by Apelin and Apela and are coupled to Gi-cAMP signaling pathway (Fig. 2, Fig. 3, Fig. 4), strongly suggests that GPR25 signaling may play important physiological and pathological roles in vertebrates more or less similar to
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Because antioxidants have a strong radical scavenging effici
2024-07-26
Because antioxidants have a strong radical scavenging efficiency, a mixture of H2O2 and antioxidants should exhibit a much weaker depolymerization process than H2O2 alone. Therefore, we expected the redox behavior of silver could be affected by the presence of the antioxidant. The schematic diagram
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br Acknowledgements We thank the National Natural Science
2024-07-26
Acknowledgements We thank the National Natural Science Foundation of China (41576156), Shandong Province Science and Technology Development Plan (2015GSF121045), Yantai Science and Technology Development Plan (2015ZH078), and the Public Science and Technology Research Funds Projects of Ocean (No.
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The incremental reduction albeit not
2024-07-26
The incremental reduction, albeit not statistically significant, in collagen I with LCZ696 compared to perindopril treated animals, may therefore be related to a more compliant ventricle in LCZ696-treated animals. This is not so surprising given the incremental anti-fibrotic effect of the active met
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Furthermore a recently published network meta
2024-07-26
Furthermore, a recently published network meta-analysis including 30 trials in patients with hypertension and diabetes demonstrated that ARBs have efficacy similar to that of ACEIs for all-cause and cardiovascular mortality (HR 0.95, 95% CI 0.73 to 1.30 and HR 1.23, 95% CI 0.64 to 2.78, respectively
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Recently the FDA approved the first blood based test for
2024-07-26
Recently, the FDA approved the first blood-based test for the detection of EGFR mutations in non-small cell lung cancer patients (http://www.fda.gov) (Voelker, 2016). This allows detection of specific, recurrent mutations, which can help the selection of the patients that could benefit from Erlotini
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