• NHEJ does not require sequence homology between the DNA ends

  2020-07-27

  

  NHEJ does not require sequence homology between the DNA ends as a prerequisite for ligation. As a result, this process can be error prone while HR is generally considered to be an error-free process. However, how a cell chooses whether to repair a DSB through NHEJ or HR, and how DNA-PK is activated

• Although the activities interactions and

  2020-07-27

  

  Although the activities, interactions and nucleocytoplasmic traffic of mucosal alpha genus HPV E7 oncoproteins have been well documented (McLaughlin-Drubin and Munger, 2009), much less is known about the cutaneous beta genus HPV E7 proteins. The cutaneous HPV8 E7 oncoprotein has a weaker interaction

• br Materials and methods br

  2020-07-27

  

  Materials and methods Discussion The present study showed that systemic administration of hUcn II results in a potent hypotensive response in urethane-anesthetized rats. Urocortin II (3, 10, and 30 μg/kg) decreased dose-dependently baseline MAP by 25–57% 10 min after peptide injection. The eff

• br Contributors br Role of the funding

  2020-07-27

  

  Contributors Role of the funding source Conflict of interest Acknowledgements This study was supported by Grants by the University of Bologna (RFO 2014 to LC and PR) and by the University of Modena and Reggio Emilia (UNIMORE FAR2014 to MZ). Introduction The urocortins (UCN 1, UCN 2 a

• Albiglutide a glucagon like peptide agonist GLP agonist

  2020-07-27

  

  Albiglutide, a glucagon-like peptide-1 agonist (GLP-1 agonist) for the treatment of type 2 diabetes (marketed as Tanzeum and as Eperzan and the US and Europe, respectively), was one of the first HSA-peptide or protein fusion product to be approved for clinical use. Whereas the APETx2 of pharmacolog

• Using four different Pichia Pink strains and two different p

  2020-07-27

  

  Using four different Pichia Pink strains and two different pPink vectors (Table 1), eight different yeast strains were obtained. The level of recombinant proteins produced was compared in the eight strains by P4H radioactive enzymatic assay. The highest enzymatic activity was obtained in the αβH4 st

• CRF and urocortin produce marked effects on

  2020-07-25

  

  CRF and urocortin 1 produce marked effects on the Estradiol Benzoate mg when administered both i.v. or directly into the CNS (Parkes et al., 2001). Systemic i.v administration of CRF and urocortin 1 cause a marked and long-lasting reduction in mean arterial blood pressure in rats Briscoe et al., 20

• Allele specific methylation has been observed in CpG islands

  2020-07-25

  

  Allele-specific methylation has been observed in CpG islands of imprinted genes.27, 32 In the present study, however, methylation of CpG1 was specific to ALL 98059 and occurred in the leukemia cells of 28% of children with ALL, but it was not found in normal leukocytes from the same patients. Methyl

• The use of AACSB accreditation as an indicator

  2020-07-25

  

  The use of AACSB accreditation as an indicator of expected performance on the CPA exam has been examined by prior studies (e.g. Barilla et al., 2008, Boone et al., 2006, Grant et al., 2002, Howell and Heshizer, 2006, Lindsay and Campbell, 2003, Marts et al., 1998). While these studies are based on d

• Magnified regions of the upregulated proteins

  2020-07-25

  

  Magnified regions of the upregulated proteins identified by MALDI-TOF are shown in Fig. 2. The identified proteins were phosphoglycerate kinase, fructose-bisphosphate aldolase class II, alcohol dehydrogenase, phosphoglyceromutase, 6-phosphogluconolactonase, malate dehydrogenase, alkyl hydroperoxide

• br Objectives br Study design Thirty KTx http www apexbt

  2020-07-25

  

  Objectives Study design Thirty KTx recipients were enrolled in this pilot study from December 2015 to May 2016. Patient demographics are presented in Table 1. The inclusion criteria were: age ≥ 18 years and CMV-IgG serostatus (D+/R−, D+/R+, D−/R+) pre-Tx. All patients were enrolled during the

• br Acknowledgment br Introduction Pesticides are largely use

  2020-07-25

  

  Acknowledgment Introduction Pesticides are largely used in agriculture to enhance food production and, to a lesser extent, to control unwanted pests and disease vectors in public health. However, these compounds are often associated with toxicity in non-target species including humans. Occupat

• br Effects of estrogen on vascular function Atherosclerosis

  2020-07-25

  

  Effects of estrogen on vascular function Atherosclerosis is a chronic inflammatory condition of the vascular wall (Figure 1) that can be converted to an acute clinical event by the induction of plaque rupture or erosion, leading to thrombosis [58]. This perpetuating process is characterized by ph

• On the other hand the

  2020-07-25

  

  On the other hand, the IL-8 promoter activity induced by the signalling cascade of the CysLT1-G300S receptor is higher than that of the WT receptor. The chemokine IL-8 is mainly involved in the recruitment and activation of neutrophils and we have previously shown that this chemokine gene is a targe

• For LAU extracted ion chromatograms of the blank t and

  2020-07-25

  

  For LAU 399, extracted SANT-1 chromatograms of the blank, t0, and t120 samples for the diagnostic product ion m/z 163.0216 are provided in Fig. S11, and extracted ion chromatograms of the t120 sample for m/z 163.0216 (diagnostic product ion), and m/z 308.1677 and 306.1522 (metabolites) are shown in

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