• The results of bisaryl ether linker study are

  2021-02-03

  

  The results of bisaryl ether linker study are shown in . It was found that the methylene linker () moderately improved the binding to the DP receptor. The increased binding potency was also diminished in the presence of plasma, possibly due to higher plasma protein binding. Other linkers, such as th

• br Introduction The dorsal periaqueductal gray matter dPAG i

  2021-02-03

  

  Introduction The dorsal periaqueductal gray matter (dPAG) is a midbrain site markedly involved in fear/anxiety-evoked responses as well as in nociception (see, for example, Bandler and Carrive, 1988, Deakin and Graeff, 1991, Fardin et al., 1984a, Fardin et al., 1984b, Litvin et al., 2007). Chemic

• br Methods br Results Our study focused

  2021-02-03

  

  Methods Results Our study focused on consecutive postural adjustments (CPAs) between IS and BS (the shaded areas on Fig. 2); that is to say, the Rx kinetics that occur after the end of an upper limb movement. It was dedicated to examining the main features of CPAs and the influence of movement

• The distorted geography on the number lines

  2021-02-03

  

  The distorted geography on the number lines of many pre-service primary teachers in this study also highlights the need to provide them with strong visual models of negative numbers and their ordering. The evidence from Indri's interview is that some standard models of negative numbers (e.g., lendin

• The two SNPs rs rs presented

  2021-02-03

  

  The two SNPs rs4818-rs4680 presented above are part of the haploblock (rs6269, rs4633, rs4818, rs4680) presenting the 3 major haplotypes which influence the enzymatic activity of COMT. This activity is inversely related to the sensitivity of pain in a chronic pain syndrome; so the haplotype (GCGG) h

• Several cholinesterase inhibitors have also been

  2021-02-03

  

  Several cholinesterase inhibitors have also been radiolabelled with 11C as potential cholinesterase imaging agents. These include 11C-donepezil, 11C-methyltacrine, and 11C-physostigmine, which also have had limited success in demonstrating the known histochemically defined cholinesterase distributio

• Not all of the biological

  2021-02-03

  

  Not all of the biological activities exhibited by progestogens (Table 1) are mediated via binding to SRs. For example, the anti-estrogenic action of progestogens in the ER 50891 is due to the progestogen-bound PR suppressing ER gene expression, and consequently the ability of the cell to respond to

• The nucleus accumbens is a

  2021-02-03

  

  The nucleus accumbens is a critical locus for ER/mGluR signaling in the context of addiction ER/mGluR signaling is regulated by caveolin proteins and palmitoylation Because of the vast implications of ER/mGluR association, it is important to understand what regulates their interaction. Such regu

• Deoxynivalenol mg br Methods br Discussion In a recent surve

  2021-02-03

  

  Methods Discussion In a recent survey among 2625 high risk patients on atorvastatin, 10.5% of patients achieved an LDL-target of and Deoxynivalenol mg level for improvement of acceptance and adherence to effective lipid lowering therapy are warranted to maximize the benefits of standard treat

• br Acknowledgements This study is sponsored

  2021-02-03

  

  Acknowledgements This study is sponsored by the Natural Science Foundation of China (grant no. 51178161), 111 Project (grant no. B13024) and the Fundamental Research Funds for the Central Universities (grant no. 2017B00914) Introduction Highway and pavement engineers are facing concrete pavem

• In this study we also conducted an analysis

  2021-02-03

  

  In this study, we also conducted an analysis comparing the expression profiling of Hh genes among the sarcomas investigated. In these tumors, the IHH gene showed a higher expression level than PTCH1 gene in RMS and SS samples (poctanoic acid receptor in human RMS cell lines as well as mouse NIH-3T3

• br Materials and methods br Results br Discussion The oestro

  2021-02-03

  

  Materials and methods Results Discussion The oestrogen agonist properties and androgen antagonist activities of parabens have been well documented by a variety of in vitro and in vivo assay systems over the past decade (Chen et al., 2007, Darbre and Harvey, 2008, Golden et al., 2005). To th

• Another milestone in the field is the de

  2021-02-03

  

  Another milestone in the field is the de novo discovery of EPAC2 and EPAC1 specific inhibitors through fluorescence-based HTS assays. Due to the excellent EPAC/PKA selectivity of ethionamide , it has been widely applied as a useful chemical probe to discriminate EPAC related signaling pathways and

• To develop antagonists selective for the mouse EP receptor

  2021-02-03

  

  To develop antagonists selective for the mouse EP1 receptor, we started with compound (), synthesized as previously described (). Diethyl dipicolinic Wortmannin () was reduced with NaBH to . Parikh–Doering oxidation of with sulfur trioxide–pyridine complex and DMSO produced the unstable aldehyde

• br Conflict of interest br Introduction Endothelin

  2021-02-03

  

  Conflict of interest Introduction Endothelin receptors are members of the superfamily of G-protein-coupled receptors (GPCRs) and central regulators of vascular tension and other physiological functions in higher eukaryotes [1]. The human endothelin system comprises the highly homologous endoth

14961 records 709/998 page Previous Next First page 上5页 706707708709710 下5页 Last page