• Taniyama et al reported a female

  2024-08-17

  

  Taniyama et al. reported a female with infertility who had a homozygous T-to-A transversion at nucleotide position g.2472 in exon 3 of the CYP17A1 gene (mutation Y201N) and decreased 17-hydroxylase and 17,20-lyase activities of deficiencies included hypertension, absent axillary hair, irregular men

• Renal Cell Carcinoma RCC is a lethal cancer with

  2024-08-17

  

  Renal Cell Carcinoma (RCC) is a lethal cancer with bad prognosis due to development of chemoresistance and recurrence of an aggressive tumor with increased tumor-angiogenesis and metastasis [7]. We have found Axl and Gas6 to be differentially presented in RCC subtypes, and Axl to correlate to tumor

• br Introduction In addition to ATP production

  2024-08-17

  

  Introduction In addition to ATP production, an important role of mitochondria in the pancreatic beta cell is anaplerosis, which is the net synthesis of citric EPZ-6438 cycle intermediates that are exported to the cytosol where they are converted to numerous other metabolites that stimulate and/o

• br Transparency document br Acknowledgments This

  2024-08-17

  

  Transparency document Acknowledgments This work has been supported by the National Eye Institute (NIH) Grant 5R01EY023315-02 (MA). This study was also supported in part by National Center for Research Resources Grant S10RR027926 for the lipid analysis and by James and Jean Culver Vision Discov

• Besides Arg overexpression our data revealed that AGEs could

  2024-08-17

  

  Besides Arg2 overexpression, our data revealed that AGEs could decrease eNOS mRNA levels, which is considered a significant cause for attenuated NO production and vasodilation. It was found recently that AGEs significantly reduce eNOS expression levels and NO bioavailability in human carotid artery

• br Introduction Natural antioxidants in vegetables

  2024-08-17

  

  Introduction Natural antioxidants, in vegetables, have gained the attention of both researchers and consumers. Vegetable amaranth (Amaranthus tricolor) is a good source of minerals, vitamins, phenolics, and carotenoids; it also contains betalains, a nitrogen containing group of natural pigments,

• AG957 br The prevalence of diabetes is increasing

  2024-08-16

  

  The prevalence of diabetes is increasing globally, and the situation is particularly alarming in Asia. The prevalence of diabetes in China has increased dramatically, from around 1% in 1980 to the most recent estimate of 9.7% according to a nationwide survey . Cumulative evidence shows that type 2

• Treatment of RAW cells with AP

  2024-08-16

  

  Treatment of RAW264.7 cocktail protease inhibitor cost with AP(+)-exosomes caused an increase in their phagocytic activity. In the presence of amastatin, phagocytic activity was not completely suppressed, suggesting that at least two components were responsible for the activity; one of which is ami

• ω-Agatoxin TK synthesis In the present study AP

  2024-08-16

  

  In the present study, AP31-B preferentially released hydrophobic ω-Agatoxin TK synthesis such as leucine and alanine from N-terminal of peptide (Fig. 4). The debittering ability of AP31-B seemed to depend on such substrate specificity, but additional tests against other hydrophobic amino acids are n

• Another research group assessed pairs of middle aged years a

  2024-08-16

  

  Another research group assessed 8503 pairs of middle-aged (ribonucleotide the twin exposed to surgery had lower scores on cognitive tests in 49% of the pairs. Twins aged 70 and older who underwent hip and knee arthroplasty scored higher on cognitive tests, even higher than those who had not undergon

• Polycyclic aromatic hydrocarbons PAHs are abundant environme

  2024-08-16

  

  Polycyclic aromatic hydrocarbons (PAHs) are abundant environmental contaminants that are produced by the incomplete combustion of organic matter, combustion engines, residential heating, WAY 208466 dihydrochloride burning, and industrial activities (Gelboin, 1980; Phillips, 1999, Phillips, 2002). S

• br KYN Acts on AhR

  2024-08-16

  

  KYN Acts on AhR To Induce Tolerogenic Immunity IDO1 and TDO2 are intracellular heme-containing metalloproteins that catalyze the committing and rate-limiting step of the KYN pathway (KP) that converts the essential amino Luciferase Reporter Assay Kit tryptophan to a series of biologically active

• membrane transport br ABCA is a sterol responsive gene

  2024-08-16

  

  ABCA2 is a sterol-responsive gene The first evidence to demonstrate that ABCA2 expression responded to sterol loading was provided in an experiment involving monocyte to macrophage differentiation in vitro. Upon sterol loading with enzymatically degraded LDL (eLDL), ABCA2 expression increased onl

• NLX a k a F or

  2024-08-16

  

  NLX-112 (a.k.a. F13640 or befiradol), exhibits nanomolar affinity at 5-HT1A receptors, and, in m6A to the 5-HT1A receptor agonists listed above, it presents exceptional selectivity and high efficacy at these receptors (Colpaert et al., 2002, Newman-Tancredi et al., 2017). Additionally, it has shown

• Since forskolin is known to act directly at the catalytic

  2024-08-16

  

  Since forskolin is known to act directly at the catalytic site of adenylate cyclases near the ATP binding (Tesmer et al., 1997), the synergistic and/or permissive effect of gonadotropins on FSK activity must occur at the level of AC itself or very near, at the level of one of its direct partner. The

14831 records 69/989 page Previous Next First page 上5页 6667686970 下5页 Last page