• It is well known that GPCR responsiveness desensitizes after

  2022-06-23

  

  It is well known that GPCR responsiveness desensitizes after prolonged exposure to agonists through several mechanisms such as receptor phosphorylation, arrestin binding and internalization (Dhami and Ferguson, 2006). Therefore, in the present work we decided to study whether group I-mGluR signaling

• br Methods br Results br Discussion

  2022-06-22

  

  Methods Results Discussion The measurement of intraocular pressure was made with a commercially available rebound tonometer, the Tonovet®. In our studies, Tonovet® underestimated the intraocular pressure in both animal models, being this effect more pronounced in the rat. To study the effe

• The structural modelling studies gave a view of arsenic medi

  2022-06-22

  

  The structural modelling studies gave a view of arsenic mediated covalent modifications possible in Cx43. In order to look for the biochemical effects of Arsenic on Cx43 and Cx43 mediated GJIC formation, and in order to further decipher the mechanism involved in Arsenic induced decreases in expressi

• br Acknowledgements br Introduction Galanin shows widespread

  2022-06-22

  

  Acknowledgements Introduction Galanin shows widespread distribution in the central nervous system (CNS) and peripheral nervous system (PNS) as well as in the immune, endocrine and endothelial vascular systems (Lang et al., 2007). Galanin controls diverse physiological processes such as arousal

• Bile acids BAs are detergent like amphipathic molecules synt

  2022-06-22

  

  Bile acids (BAs) are detergent-like amphipathic molecules synthesized from cholesterol in the liver, stored in the gallbladder, and released into the intestine after food intake in order to facilitate the next week of dietary lipids and liposoluble vitamins. BAs travel along the intestine and once

• CC is a widespread disorder affecting up to of people

  2022-06-22

  

  CC is a widespread disorder affecting up to 20% of people worldwide, which also deteriorates the quality of life of patients and causes a substantial economic burden to society. There are 3 categories of CC: normal-transit constipation, slow-transit constipation and defecatory or rectal evacuation d

• Hardy et al had demonstrated the

  2022-06-22

  

  Hardy et al. had demonstrated the role of GPR40 in mediating the proliferative effect of the FFA oleate's in breast cancer cells, and found that such effect can be reversed by silencing of GPR40 [14]. Similarly we have observed that inhibition of GPR40 function by its antagonist GW1100 inhibited cel

• Main Text FFAR GPR is a

  2022-06-22

  

  Main Text FFAR1 (GPR40) is a long-chain fatty Silicristin (LCFA) receptor highly expressed and enriched in enteroendocrine cells, where it senses LCFAs generated from dietary triglycerides, and in pancreatic islet cells, where it acts as a powerful stimulator of insulin secretion. However, the phy

• We have presented evidence that only muscle FBPase is

  2022-06-22

  

  We have presented evidence that only muscle FBPase is detectable within HL-1 cells. This is consistent with past findings of the Eschrich's group, which showed that in rat heart sphk expression of FBPase is almost exclusively limited to the muscle isozyme [3]. Results of our preliminary experiment

• Mammals and birds are sensitive either

  2022-06-22

  

  Mammals and birds are sensitive either to hypo or hyper glycemia. In contrary some frogs when freezing/thawing experience very high glycemia (Storey and Storey, 1986). Nevertheless when the effect of temperature on Fru-2,6P2 concentration was investigated, the constant glucose level in frogs kept at

• br Conflicts of interest br Funding This work was

  2022-06-22

  

  Conflicts of interest Funding This work was supported by the Higher Education Commission Pakistan start-up research grant to Anjum Riaz. Introduction Distraction osteogenesis (DO) is an endogenous tissue engineering technology used to repair skeletal including craniofacial deformities, in

• Similar to in vitro data in vivo studies have also

  2022-06-22

  

  Similar to in vitro data, in vivo studies have also revealed modulation of TLR4-induced inflammatory responses by AEA. The proposed AEA reuptake inhibitor AM404 has been shown to attenuate TLR4-induced increases in plasma levels of IL-6 and IL-1β, the latter effect mediated by CB1 receptor activatio

• GSK2656157 Classical drugs target the viral enzymes reverse

  2022-06-22

  

  Classical drugs target the viral GSK2656157 reverse transcriptase (RT), protease and integrase (IN) [[4], [5], [6]]. Raltegravir (ISENTRESS/MK-0518) is the prototypical integrase strand transfer inhibitor (INSTI) leading to an extremely strong reduction in viral load [7] and it has been approved fo

• br Conclusion We have demonstrated that ETB receptors negati

  2022-06-22

  

  Conclusion We have demonstrated that ETB receptors negatively regulate the expression of AT1 receptors in renal proximal tubule akt inhibitors from WKY rats but not in SHRs. Short-term activation of the ETB receptor increases AT1 receptor phosphorylation in WKY cells but decreases it in SHR cell

• The comparatively low number of H R

  2022-06-22

  

  The comparatively low number of H1R agonists is contrasted by the high number of diverse H1R antagonists. Based on pharmacological classification, they are grouped into different generations by considering their target as well as side effects profile. The first generation “antihistamines” consist of

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