• br Conclusion Interactions between neurons and

  2022-09-13

  

  Conclusion Interactions between neurons and astrocytes depend on the spatial configuration of their contacts. Therefore, changes of astrocyte morphology may impact various physiological mechanisms ranging from glutamate uptake and potassium homeostasis to modulation of synaptic transmission and p

• Limited efforts were made to exploit

  2022-09-09

  

  Limited efforts were made to exploit the naturally-occurring antigen-specific Treg for ex vivo expansion. This study sets up a reproducible protocol for the expansion of insulin-specific Treg isolated from NOD mice. These compound 3k exhibited higher suppressive capacity compared to the polyclonal

• br Methods and materials br Acknowledgements

  2022-09-09

  

  Methods and materials Acknowledgements The authors thank the NIH AIDS Reagent Program for providing the materials and reagents. The HIV-1 1084i envelope gene was a generous gift from Dr. Charles Wood. This work was supported in part by grants to S.-H. X. from the Bill and Melinda Gates Foundat

• Additionally increased GLO gene expression protein expressio

  2022-09-09

  

  Additionally, increased GLO1 gene expression, protein expression, and activity have been reported in a variety of cancers, including breast,22, 23, 24 pancreatic, melanoma, and prostate.27, 28, 29 Vince and Daluge proposed that inhibitors of GLO1 could serve as anti-tumor agents, by increasing conce

• Tamoxifen is still the most frequently used selective estrog

  2022-09-09

  

  Tamoxifen is still the most frequently used selective estrogen receptor mediator (SERM) in premenopausal women suffering from estrogen receptor positive (ER+) breast carcinomas [15]. Although this therapy has been proven very successful, about 20–30% of ER+ breast tumors will not respond, or acquire

• Through a large scale phylogenetic analysis

  2022-09-09

  

  Through a large-scale phylogenetic analysis of UDG superfamily in more than 1000 completely sequenced genomes, it is shown that family 3 UCB 35625 can be separated into two clades with the traditional family 3 SMUG1 as one of them (Fig. 1) [31]. UDG enzymes in another clade are present in eubacteri

• In this study we find that DH CBD induces analgesic

  2022-09-09

  

  In this study, we find that DH-CBD induces analgesic effects on inflammatory but not acute pain and the nop receptor level of spinal α1 GlyRs increased after CFA paw injection. These results suggest that GlyR α1 is only involved in chronic pain. A possible explanation is that once the expression of

• br Conclusion Membrane transporters remain

  2022-09-09

  

  Conclusion Membrane transporters remain relatively understudied in human disease, especially TBI (Cesar-Razquin et al., 2015), and considerably less is known in terms of expression, function and substrates of membrane transporters in pediatric patients. However, their importance in maintaining cl

• br Methods and materials br Results Overall

  2022-09-09

  

  Methods and materials Results Overall, free glutamate intakes in US children and adults are shown in Table 1. The sample-weighted mean intake of crude free glutamate was 258 mg/d for children and 322 mg/d for adults. Furthermore, the corresponding energy-adjusted value was 136 mg/1000 kcal and

• br Introduction L Glutamate is

  2022-09-09

  

  Introduction L-Glutamate is one of the most prevalent excitatory signaling molecules in the central nervous system (CNS) (Salazar et al., 2016) and plays a crucial role in a variety of gpr44 inhibitor functions such as memory and learning (Danbolt, 2001, Nedergaard et al., 2002). At elevated conc

• The functionally crucial arginine within M is not encoded

  2022-09-09

  

  The functionally crucial arginine within M2 is not encoded by the gluR2 gene, but rather arises within the pre-mRNA by editing of a codon for the neutral glutamine residue25, 26. RNA editing at the Q/R site is specific to GluR2 and is extremely efficient. In neonatal and adult rat brain, almost 100%

• BCTC Hippocampal lesioned mice were less

  2022-09-09

  

  Hippocampal-lesioned mice were less able to withhold responding during a DRL-10 requirement (i.e. when the animals had to wait 10s between lever presses), and were thus less efficient than sham operated controls. In contrast, GluR-A−/− mice did not differ from wild-type mice when the DRL requirement

• Ulimorelin also known as TPZ is a macrocyclic

  2022-09-09

  

  Ulimorelin, also known as TPZ101, is a macrocyclic molecule that is a potent agonist of the ghrelin receptor (Hoveyda et al., 2011). Due to its ability to stimulate gastrointestinal motility, ulimorelin has been evaluated as a possible treatment in gastroparesis (Ejskjaer et al., 2010), ileus (Frase

• br Methods br Results br Discussion

  2022-09-09

  

  Methods Results Discussion In this study, we investigated temperature effects on Vj-gating properties of two cardiac GJs. In the case of Cx45 GJs, increased temperature from 22 °C to 28 °C (or 32 °C) led to an accelerated Vj-dependent deactivation with little change in the extent of Vj-gati

• The Notch cleavage efficiency of Aph aS containing complexes

  2022-09-09

  

  The Notch-cleavage efficiency of Aph1aS containing complexes was lower than that of Aph1aL γ-secretases, especially in combination with PS2, suggesting that Aph1aS is a determinant of low Notch-cleavage specificity, considering that the different subcellular localization of PS1 and PS2 didn't affect

15360 records 406/1024 page Previous Next First page 上5页 406407408409410 下5页 Last page