• N,N-Dimethylsphingosine The analysis of the profile

  2024-02-10

  

  The analysis of the profile of protein phosphorylation in MMS-treated N,N-Dimethylsphingosine confirmed that both the ATM and ATR pathways were activated in S-phase blocked cells. Interestingly, phosphorylation of Chk1 was observed 24h after MMS-treatment both in AT- and ATM-inhibited cells, whilst

• Hypoxia induced replication arrest has been demonstrated in

  2024-02-10

  

  Hypoxia-induced replication arrest has been demonstrated in a variety of organisms in addition to mammals; including Zebrafish , , and (brine shrimp) which have been shown to survive for 4 years and longer in anoxic conditions . Despite this breadth of study, little is known about the mechanism of h

• Apelin APJ triggers a variety of

  2024-02-10

  

  Apelin/APJ triggers a variety of cellular signaling pathways (Fig. 1). Recent studies from our laboratory showed that apelin-13 induces vascular smooth muscle cell (VSMC) proliferation by the upregulation of Cyclin D1 expression, which is involved in an ERK-dependent activation of Jagged-1/Notch3 si

• Olomoucine mg Use of RASB is associated with potential conce

  2024-02-09

  

  Use of RASB is associated with potential concerns about side effects such as acute kidney injury or hyperkalemia, and clinicians are reluctant to prescribe RASB in patients with severe renal dysfunction (estimated GFR Conclusions Conflict of interest Acknowledgement Introduction Renin-an

• As patients with type diabetes are known to

  2024-02-09

  

  As patients with type 2 diabetes are known to be hyperinsulinemic per se, this relationship between insulin/IGF1 receptor and AR may point towards a causal role of insulin in AR upregulation. Indeed, this is supported by several previous observations. Beyond the already mentioned AR activation by in

• Although several ARIs have reached

  2024-02-09

  

  Although several ARIs have reached various phases of clinical experimentation however most of them have been withdrawn either due to an insufficient bioavailability, their poor efficacy or adverse side effects. Currently Epalrestat is in clinical use for the treatment of diabetic neuropathy. The sid

• Molecular docking is widely used to predict

  2024-02-09

  

  Molecular docking is widely used to predict the interaction between an enzyme and its inhibitors. This is a computational simulation approach that can be used as a tool to investigate the structure-activity relationship of ACE inhibitory peptides (Goodsell, 2009). It has been recently shown that ACE

• The most potent compounds within the current series of

  2024-02-09

  

  The most potent compounds within the current series of compounds were therefore , , , , and , with IGF-1, human recombinant possessing the best selectivity towards the lyase reaction in comparison to the hydroxylase reaction, indeed, this compound was found to possess an IC value of 1210nM agains

• Besides Arg overexpression our data revealed that

  2024-02-07

  

  Besides Arg2 overexpression, our data revealed that AGEs could decrease eNOS mRNA levels, which is considered a significant cause for attenuated NO production and vasodilation. It was found recently that AGEs significantly reduce eNOS expression levels and NO bioavailability in human carotid artery

• br Material and methods br Results br Discussion Asparagine

  2024-02-07

  

  Material and methods Results Discussion Asparagine, arginine, leucine, methionine, and glutamine are the essential growth hormone secretagogue for cancer cells and intensively investigated for the development of selective targeted therapeutics. Among them, asparagine depleting bacterial en

• In a human intervention study

  2024-02-07

  

  In a human intervention study, blood GSH levels were evaluated over 6 wk in 18 male participants subjected to strenuous aerobic training and a dietary supplement of 1 g of WPI/kg of body mass per day. Blood GSH levels were significantly lower in those subjects who performed exercise that those who d

• The electrokinetic remediation technique is carried out with

  2024-02-07

  

  The electrokinetic remediation technique is carried out with a low-level direct current, and the pollutants in soil can be transported and removed by the electric field [19]. This works well even in soil with low permeability via electro-osmotic flow and electro-migration [20]. The electrokinetic pr

• MAPs require divalent transition metal

  2024-02-07

  

  MAPs require divalent transition metal ions as cofactors for activity [21]. Previous studies on MAPs from different organisms indicate cobalt ions to be the most preferred divalent metal activator [22]. However, MAPs also exhibit activity with other divalent cations like Mn(II), Ca(II), Ni(II) or Fe

• br Concluding Remarks and Future Perspectives While postmort

  2024-02-07

  

  Concluding Remarks and Future Perspectives While postmortem human lumiracoxib material is relatively sparse and has inherent limitations as discussed above, additional investigations could benefit from analysis of in vitro cellular models to corroborate findings in patient material. Generation o

• Gliomas and Aldehyde Dehydrogenase Aldehyde dehydrogenases A

  2024-02-07

  

  Gliomas and Aldehyde Dehydrogenase Aldehyde dehydrogenases (ALDHs) are key metabolic enzymes involved in regulation of glycolysis/gluconeogenesis pathways as well as in the detoxification of endogenous and exogenous aldehydes, regulating cell function and homeostasis. ALDHs play important roles in

14925 records 179/995 page Previous Next First page 上5页 176177178179180 下5页 Last page