• Our previous studies have shown that in

  2020-08-10

  

  Our previous studies have shown that in a preimplantation mouse embryo the proportion of inner to outer cells (i.e. precursors of ICM and TE, respectively) is regulated by a different frequency of differentiative cell divisions at the 8- and 16-cell stages. Low number of inner blastomeres generated

• An important focus of the

  2020-08-10

  

  An important focus of the present study has been the interaction of HUVECs with extracellular matrix in the regulation of angiogenesis. Matrigel is a gelatinous protein extract secreted by Engelbreth–Holm–Swarm mouse sarcoma cells, and is considered to be a good model of the extracellular matrix (K

• br Introduction Cerebral stroke causes an efflux of various

  2020-08-10

  

  Introduction Cerebral stroke causes an efflux of various groups of progenitor and stem cells from bone marrow to bloodstream and the levels of these cells correlate with neurological status of stroke patients (Gójska-Grymajło et al., 2012, 2018). It is thought that paracrine factors produced by t

• br Material and methods br Results br

  2020-08-10

  

  Material and methods Results Discussion The results show for the first time that DDRs may be involved in the pathogenic mechanisms of neurodegenerative diseases. We found that DDR1 and DDR2 levels are up-regulated in post-mortem AD and PD brains, suggesting that these receptors play a role

• br Acknowledgments br Introduction Ubiquitin ligases limit t

  2020-08-10

  

  Acknowledgments Introduction Ubiquitin ligases limit the stability and activity of substrates by targeting them for proteasomal-dependent degradation. Siah is a two-member family of ubiquitin ligases implicated in control of key cellular processes. Among those, Siah ligases control prolyl hydr

• The inhibition of DNMT using AZA dC or

  2020-08-08

  

  The inhibition of DNMT1 using 5-AZA-dC or DNMT1 siRNA increased TIMP2 protein and mRNA expression, suggesting that TIMP2 expression is down-regulated by DNA methylation in the HDFs. In addition, 5-AZA-dC treatment led to a dose-dependent decrease of DNMT1 protein expression. 5-AZA-dC is a cytosine a

• AZD6738 Although in vitro and in vivo immunosuppressive effe

  2020-08-08

  

  Although, in vitro and in vivo immunosuppressive effects of female steroids have been described in fish (Yamaguchi et al., 2001, Law et al., 2001), their mode of action was not evaluated in detail. Consequently, it is of considerable interest to investigate the intracellular pathways that regulate t

• Although many of the genetic changes

  2020-08-08

  

  Although many of the genetic changes remain to be elucidated, there is evidence to support a difference in incidence and rate of rupture of cerebral aneurysms between men and women, and between pre- and postmenopausal women, suggesting that aneurysm formation may be affected by hormonal changes.18,

• Although Bach is expressed in diverse cell types no

  2020-08-07

  

  Although Bach1 is expressed in diverse cell types, no clear defects are observed in Bach1-deficient mice under normal conditions [10]. Bach1-deficient mice also exhibit elevated disease tolerance in various models, including atherosclerosis in ApoE double-knockout mice [38], lung damage after high o

• DNA damage represents a persistent threat to genomic

  2020-08-07

  

  DNA damage represents a persistent threat to genomic stability. A critical link exists between DNA mutation, chromosomal rearrangement and cancer development. In myeloid malignancies, various chromosomal translocations and/or mutations increased cellular reactive oxygen species (ROS), followed by DS

• br Results br Discussion A significant decrease in

  2020-08-06

  

  Results Discussion A significant decrease in fluorescence was observed after the treatment of pure DNA with alkylating compounds. This decrease was characterized by a dose-response relationship. Mass spectrometry and additional fluorescence measurements ruled out the covalent modification of E

• Bioactive Compound Library australia Many filarial species h

  2020-08-06

  

  Many filarial species harbor an endosymbiotic bacterium of the genus Wolbachia. A recent investigation of Wolbachia distribution in 35 filarial species including 28 species and 7 genera and/or subgenera have shown that 37% of them harbor Wolbachia (Ferri et al., 2011). In filarial nematodes, Wolbach

• In contrast NetPhos analysis predicted that

  2020-08-06

  

  In contrast NetPhos2.0 analysis predicted that Ser185 could be a substrate of the kinases CamKII and PKA. The in vitro kinase reactions with purified kinases showed that CamKII was able to phosphorylate GST-RhoB (data not shown) while on the contrary PKA did not produce any detectable phosphorylated

• Although CYP E is also suspected of being the major

  2020-08-05

  

  Although CYP2E1 is also suspected of being the major catalyst of CCl4 reduction in humans [7], the role of the various human CYP450 forms in CCl4 metabolism over a range of CCl4 concentrations has not been established. An understanding of which CYP450 forms contribute to CCl4 metabolism would provid

• Adaptation to psychological or physiological stressful

  2020-08-05

  

  Adaptation to psychological or physiological stressful circumstances requires integration of behavioral, neuroendocrine, and autonomic responses to maintain homeostasis. The LC is regarded as a part of the central ‘stress circuitry’, which is robustly activated after stressful stimuli in experimenta

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